Inhibition of Prostate Cancer Skeletal Metastases by Targeting Cathepsin K PRINCIPAL INVESTIGATOR:
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منابع مشابه
Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
The skeleton is the most common site of metastasis in patients with advanced prostate cancer. Despite many advances in targeting skeletal metastases, the mechanisms behind the attraction of prostate cancer cells to the bone are not known. Osteoclast cathepsin K, due to its ability to effectively degrade bone matrix collagen I, has been implicated in colonization and growth of prostate tumours i...
متن کاملDiagnostic uncertainty of isolated skull lesion in prostate cancer- Role of SPECT/CT
Skeletal involvement is the second most common site of metastases after lymph nodal metastases in patients with prostate cancer. The skeletal metastases from prostate cancer are osteoblastic in nature and show increased tracer avidity on the bone scan. Focal tracer avid lesion in skeleton especially in skull requires the careful examination by further investigation. The patients with skull meta...
متن کاملAntibody-Mediated Targeting of Alpha PDGF Receptor to Inhibit the Progression of Skeletal Micro-Metastases. PRINCIPAL INVESTIGATOR:
s Innovative Minds in Prostate Cancer Today, CDMRP. “The alpha-receptor for Platelet-Derived Growth Factor is transactivated by bone marrow and its antibody-mediated targeting counteracts the establishment and progression of skeletal metastases”. Orlando FL. Presentations University of Illinois at Chicago – Department of Biopharmaceutical Sciences. College of Pharmacy. “Molecular and mechanisms...
متن کاملTITLE: Effect of a High Bone Turnover State Induced by Estrogen Deficiency on the Development and Progression of Breast Cancer Bone Metastases PRINCIPAL INVESTIGATOR:
s: 1.Abstract (poster) from the Skeletal Complications of Malignancy IV Meeting; April 2005; Bethesda, MD: Aromatase Inhibition Results in Lower Bone Density Than Ovariectomy in Mice an Effect Prevented by Bisphosphonates. W.M. Kozlow, K. Mohammad, R. McKenna, M. Niewolna and T.A. Guise. Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, USA.
متن کاملTargeting factors involved in bone remodeling as treatment strategies in prostate cancer bone metastasis.
Prostate cancer is the most commonly diagnosed cancer in men within the western world and the third leading cause of cancer-related deaths. Even if the cancer is considered localized to the prostate, there is a 15% to 20% incidence of subsequent metastatic disease. Prostate cancer has a very high proclivity for metastasizing to bone, with approximately 90% of men with advanced disease having sk...
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تاریخ انتشار 2009